| abstract |
PCT No. PCT/GB95/00228 Sec. 371 Date Sep. 26, 1996 Sec. 102(e) Date Sep. 26, 1996 PCT Filed Feb. 6, 1995 PCT Pub. No. WO95/21819 PCT Pub. Date Aug. 17, 1995 <IMAGE> (I) The present invention relates to compounds of formula (I) wherein n is 3 and where any carbon atom of (CH2)n may be substituted by R4 and/or R5; X represents O or S; R1 represents (CH2)qphenyl, wherein q is 0, 1 , 2 or 3 which may be optionally substituted in the phenyl ring; R2 represents aryl selected from phenyl and naphthyl; heteroaryl selected from indazolyl, thienyl, furyl, pyridyl, thiazolyl, tetrazolyl and quinolyl; benzhydryl; or benzyl; wherein each aryl or heteroaryl moiety may be substituted; R4 and R5 each independently represent H, halo, C1-6alkyl, oxo, CO2Ra or CONRaRb; R6 represents H or C1-6alkyl; R7 represents trifluoromethyl, C2-6alkenyl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, (CH2)pNR9R10, CO2R16, CONR9R10, (CH2)pCO2R16, (CH2)pCONR9R10, (CH2)pNR9COR16, (CH2)pNHSO2R11, (CH2)pOR16, (CH2)pOC(O)R9 or (CH2)pOC1-4alkylCOR17 or C1-6alkyl substituted by a hydroxy group; R8 repents H, CORa, CO2Ra, COCONRaRb, COCO2Ra, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, C1-6alkyl optionally substituted by a group selected from (CO2Ra, CONRaRb, hydroxy, cyano, CORa, NRaRb, C(NOH)NRaRb, CONHphenyl(C1-4alkyl), COCO2Ra, CONHNRaRb, C(S)NRaRb, CONRaC1-6alkylR12, CONR13C2-6alkynyl, CONR13C2-6alkenyl, COCONRaRb, CONRaC(NRb)NRaRb, CONRaheteroaryl, and optionally substituted phenyl or C1-6alkyl, optionally substituted by oxo, substituted by an optionally substituted aromatic heterocycle; Ra and Rb each independently represent H, C1-6alkyl, trifluoromethyl or phenyl optionally substituted by C1-6alkyl, halo or trifluoromethyl. The compounds are of particular use in the treatment of pain, inflammation, migraine and emesis. |