| abstract |
PCT No. PCT/GB95/00280 Sec. 371 Date Jul. 15, 1996 Sec. 102(e) Date Jul. 15, 1996 PCT Filed Feb. 10, 1995 PCT Pub. No. WO95/21813 PCT Pub. Date Aug. 17, 1995This invention concerns compounds of generic formula: <IMAGE> (I) or a pharmaceutically acceptable salt thereof, where the dotted line represents an optional bond, one of R1 and R5 represents hydrogen, C1-C6 alkyl, C7-C16 aralkyl, -(CHR6)nCHR7CN, -(CHR6)nCHR7CONH2, -(CHR6)nCHR7COOR8, -(CHR6)nCHR7CH2OH wherein n is 0 or 1, R6 and R7 independently represent hydrogen, C1-C6 alkyl- or C7-C16 aralkyl-, and R7 also represents hydroxy(C1-C6)alkyl-, (C2-C7)alkanoyloxy(C1-C6)alkyl-, (C1-C6alkoxy)carbonyl- and R8 is hydrogen or C1-C6 alkyl; the other of R1 and R5 is hydrogen, C1-C6 alkyl or C7-C16 aralkyl; R3 is C6-C10 aryl or heteroaryl group optionally substituted by one or more substituents the same or differnet, R2 and R4 independently represent hydrogen, or a group of formula -CRaRbRc where Ra, Rb and Rc are independently selected from hydrogen, C1-C6 alkyl, optionally substituted C6-C10 aryl, optionally substituted heteroaryl, C1-C6 alkyl substituted by optionally substituted C6-C10 aryl or heteroaryl or R2 also represents COR11 where R11 is C1-C6 alkyl, C1-C6 alkoxy or an optionally substituted (C6-C10 aryl)alkyl or a heteroaryl alkyl radical; one of Y and Y1 is <IMAGE> where R13 represents hydrogen, C1-C6 alkyl or C7-C16 aralkyl; the other of Y and Y1 is -CHR12- where R12 is hydrogen, C1-C6 alkyl or C7-C16 aralkyl, which compounds have pharmaceutical uses conferred by their ability to block voltage gated potassium channels. |