http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0743842-B1

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assignee http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_25075351c1dbea503efe80e53c0e11bb
classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-703
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-7061
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-465
filingDate 1995-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2003-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b058931141aed8bab2c1157e282ebb2f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c019df8ecee061924b66726f802d2b6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9b3e51080fa193a22bc4678e05c3ce0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c644b60ebe413f95e99fba5aa09ce26c
publicationDate 2003-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0743842-B1
titleOfInvention Drug-containing adhesive composite transdermal delivery device
abstract A method for making a transdermal drug delivery device for heat sensitive and volatile drugs is disclosed. The device contains a drug-containing adhesive composite layer having an impermeable backing material laminated to the distal surface thereof and a proximal peelable impermeable backing material adapted for removal for administering a drug to the skin or mucosa laminated to the proximal surface thereof. The method comprising the steps of providing first and second adhesive laminates each comprising a drug permeable adhesive layer having laminated to one surface one of said backing materials and having the opposing surface exposed. The drug, in gelled form and optionally containing additives such as enhancers and preservatives, is extruded onto at least one exposed surface of the first or second adhesive laminate followed by laminating together the exposed surfaces of the first and second adhesive laminate such that the adhesive layers and gelled drug are combined to form the drug-containing adhesive composite layer having the distal and proximal surfaces covered by the respective backing materials. The adhesives used in making up the laminates may be the same or different provided the drug is compatible with the adhesive. The process is particularly adaptable to the formulation of nicotine-containing patches. Drug delivery devices made according to the disclosed method and a method of using these drug delivery devices are also described.
priorityDate 1994-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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