| abstract |
The present invention provides processes for preparing compounds of formula In wherein n R 1 is -H, OH, or OR 3 , in which R 3 is a hydroxy protecting group; and n R 2 is -H, -OH, or OR 4 , in which R 4 is a hydroxy protecting group, and for preparing compounds of formula VIIn wherein n R 1 is -H, -OH, or OR 3 , in which R 3 is a hydroxy protecting group; n R 2 is -H, -OH, or OR 4 , in which R 4 is a hydroxy protecting group; n R 5 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino; n R 6 is bromo, chloro, iodo, or an activating ester group; and n n is 2 or 3. n Also provided are processes for preparing compounds of formula VII in addition to intermediates of formula IXn wherein n R 1' is -OH, or -OR 3 , in which R 3 is a hydroxy protecting group; and n Z is bromo, iodo, triflate, or -B(OH) 2 . |