| abstract |
PCT No. PCT/JP95/00025 Sec. 371 Date Nov. 29, 1996 Sec. 102(e) Date Nov. 29, 1996 PCT Filed Jan. 11, 1995 PCT Pub. No. WO95/19363 PCT Pub. Date Jul. 20, 1995This invention provides compounds of the following chemical formula or their pharmaceutically-acceptable salts: <IMAGE> (I) wherein R is hydrogen or chloro. Also, the present invention provides a process for the production of the compound of formula I, which comprises cultivating a microorganism having the identifying characteristics of Aspergillus fischeri var. thermomutatis ATCC 18618 or the like, and then isolating the compound of formula I from the fermentation broth. The pyrrolobenzoxazine compounds of formula I of this invention have broad antiparasitic activity, and thus are useful as antiparasitic agents, especially as anthelmintics. |