| abstract |
The present invention provides a method of treating or preventing in a subject an intestinal disorder caused by an elevated level of TNF in the lumen of the intestine of the subject. The method involves administering to the subject an agent which reduces the action of the intralumenal TNF or reduces the production or accumulation of intralumenal TNF. The agent may be any of a number of known anti-TNF agents, however, it is preferred that the agent is an anti-TNF antibody. It is also preferred that the agent is administered directly into the intestine. |