abstract |
A class of 1,5-diphenyl pyrazoles is described for the treatment of inflammation, including treatment of pain and disorders such as arthritis. Compounds of particular interest are of formula (I), wherein R1 is methylsulfonyl; wherein R2 is selected from -CF¿3?, -CF2Cl, -CF2H, -CF2CF3 and -CF2CF2CF3; and wherein R?3¿ is fluoro or chloro; or a pharmaceutically-acceptable salt thereof. |