| abstract |
Disclosed are quinazoline derivatives represented by formula (I):n wherein R 1 represents hydrogen, lower alkyl, alkenyl, or aralkyl; R 2 , R 3 , R 4 , and R 5 represent hydrogen, lower alkyl, lower alkoxy, lower alkanoyl, or the like; R 6 , R 7 , R 8 , and R 9 represent hydrogen, lower alkyl, lower alkoxy, aralkyloxy, or the like, or any adjoining two of them are combined to form methylenedioxy or the like; R 10 represents hydrogen, lower alkyl, or the like; R 11 and R 12 represent hydrogen, lower alkyl, cycloalkyl, phenyl, or aralkyl, or R 11 and R 12 are combined together with N to form a heterocyclic group; and n represents 0, 1 or 2, nand pharmaceutically acceptable salts thereof. n These compounds have adenosine uptake inhibitory activity and are useful for the protection of myocardium and for the prevention or treatment of inflammation such as leg and foot edema. |