Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2817954cd008bcd609a4c4eb49050be |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-1203 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-1217 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-22 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-569 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-095 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
filingDate |
1994-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c427199addbf93f9c07e376f416f0983 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d1753fceb1f4ff75e096b5f287ea411 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05da9fa89a2400aa67bb5d9bf6efebc6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5818b6bc554622056b0be6bf215c7599 |
publicationDate |
1996-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
EP-0725792-A1 |
titleOfInvention |
RECOMBINANT PilC PROTEINS, PROCESS FOR PRODUCING THEM AND THEIR USE |
abstract |
A recombinant gene sequence (I) for a protein having the biological activity of the PilC-protein (part of the pathogenic type 4 pilus or bacteria) comprises a section encoding a signal peptide that undergoes phase variations (section SPVP) and a homopolymer nucleotide sequence (HNS); the section is modified by either (a) a modification of HNS to an invariable heteropolymer sequence or (b) substitution of section SPVP by a sequence that does not undergo phase variation, but which encodes a signal peptide compatible with the PilC-protein secretion, so that expression of (I) in a host cell is not influenced by phase variation. Also claimed are: (i) a vector carrying (I), (ii) a host contg. a vector as above, (iii) a method for the prodn. of essentially pure protein with PilC-protein activity, (iv) proteins with PilC-activity and (v) antibodies inhibiting the binding of (iv) to a corresp. receptor and (vi) a cellular receptor or its analogue for type-4-pilus carrying bacteria binding (iv). |
priorityDate |
1993-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |