http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0724573-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c902faf6ae746c51fc8010672fc22894 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6512 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6512 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 1994-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37a2422a39a27d96945b871d19623044 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59efd79178398150c7394edf90c542ea |
| publicationDate | 1996-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0724573-A1 |
| titleOfInvention | Pyrimidinones as antiarthritic and anti-inflammatories |
| abstract | Compounds useful in the treatment of inflammation structurally represented as formula (I) or pharmaceutically acceptable salts thereof, wherein R2 is a) (CH¿2?)n-Y i) where n is 1 then Y is C1-C6 alkoxy, morpholinyl, piperdinyl, pyrrolidinyl, phenoxy, phenylthio, phenylsulfonyl, phenylsulfinyl, -NHC(O)-C1-C6 carboxylic acid, N3, NH2, diethylamino, hydrogen (provided R?4¿ is benzyloxy), halogen (provided R3 is a C¿1?-C6 alkyl) or CH('EWG')2 where 'EWG' is an electron withdrawing group each individually selected from the group consisting of CO2R?6¿ or PO(OR7)2, or ii) n is 2 then Y is CH('EWG')2, or b) a terminal olefin substituted with i) an aryl or heteroaryl, ii) hydroxyl and a C1-C6 alkyl, phenyl or (CH2)m-CO2R6 where m is 1 to 3, or c) C¿3?-C6 cycloalkyl (optionally substituted with a halogen, (PO(OC2H5)2)2 or CN); R?3¿ is hydrogen or C¿1?-C6 alkyl; R?4¿ is hydrogen, hydroxyl, C¿1?-C6 alkyl, alkoxy, benzyloxy or phenoxy; R?5¿ is hydrogen, halogen, C¿1?-C6 alkyl, C1-C6 alkoxy, phenoxy, C1-C6 alkylthio, thiophenyl, NH2, aryl (except that R?5¿ is other than phenyl when R4 and Y are both hydrogen) or heteroaryl; R6 is H, C¿1?-C6 alkyl, benzyl, phenyl, phenyl substituted with one to five F, C1, Br, I, NO2, OCH3 or C1-C4 alkyl; and R?7¿ is H, C¿1?-C6 alkyl, benzyl, phenyl, phenyl substituted with one to five F, C1, Br, I, NO2, OCH3 or C1-C4 alkyl, or where both R?7¿'s are taken together to form a CH¿2?-CH2, CH2-CH2-CH2 or CH2-C(CH3)2-CH2 whereby a heterocyclic ring containing the bonded P atom and the two O atoms is formed. The compounds are useful as anti-inflammatory and antiarthritic agents. |
| priorityDate | 1993-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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