http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0721448-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2227a4ee4bf2e2b230299ca24fd3308a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-34 |
| filingDate | 1994-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f419c6c4d4653ac91ff0958487914ec8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93fc07b837ce466d09b1c8716d69925b |
| publicationDate | 1996-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0721448-A1 |
| titleOfInvention | Chiral nitriles, their preparation and their use for the manufacture of verapamil and analogues |
| abstract | A process for preparing a substantially single enantiomer (R &cir& _ or S &cir& _) of R'-NH-(CH2)3-C(Ar) (CN)-R, the process comprising reacting together R-CH(Ar)-CN and X-(CH2)3-A to give X-(CH2)3-CH(Ar) (CN)-R, reacting that with methylamine to give R'-NH-(CH2)3-C(Ar) (CN)-R, and resolving that into a substantially single enantiomer thereof, wherein Ar is aryl, R and R' are each independently C1-20 alkyl, X is a halo atom and A is a leaving group and the resolution is carried out using a chiral acid. The process is particularly useful for preparing verapamil, and analogues thereof, in single enantiomeric form. |
| priorityDate | 1993-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.