| abstract |
Compounds of formula I. wherein R 1 is a 2-R A -3-R B -phenyl radical, 2-R A -4-R C -phenyl radical, 2-R A -pyridin-3-yl radical, 3-R A -pyridin-2-yl radical or 1-R D -indol-3-yl radical, where one of the radicals R A and R B is an aliphatic or heterocycloaliphatic-aliphatic radical or optionally aliphatic, araliphatic or heteroaraliphatic etherified hydroxy and the other is hydrogen, an aliphatic radical or optionally esterified or amidated carboxy, R C is hydrogen, an aliphatic radical, if appropriate aliphatic, araliphatic, heteroarylaliphatisch or heterocycloaliphatischaliphatisch etherified hydroxy or an optionally heteroaliphatic substituted amino group, and R D is an aliphatic, araliphatic or heteroaliphatic radical, one of the radicals X 1 and X 2 is carbonyl and the other is methylene, R 2 is an aliphatic radical , R 3 represents optionally aliphatically substituted amino, R 4 represents an aliphatic or araliphatic radical and R 5 represents an aliphatic or cycloaliphatic-aliphatic radical or an optionally hydrogenated and / or oxo-substituted hetero aryl radical or a lower alkyl radical substituted by a carbon atom and optionally hydrogenated and / or oxo-substituted heteroaryl or heteroaliphatic radical, and their salts have renin-inhibiting properties and can be used as antihypertensive active pharmaceutical ingredients. |