| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eb9c6b40161bafe7bd55f0b4defcea04 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56972 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-91 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-569
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-577
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 |
| filingDate |
1994-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff15ea19ccd9742fa1c990f9b4d5121a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19702006c591bb0a9cb1ebfb7e59a0cb |
| publicationDate |
1996-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0714510-A1 |
| titleOfInvention |
Natural killer cell-specific antigen and antibodies that identify the same |
| abstract |
The invention provides a novel natural killer (NK) cell-specific molecule consisting of a glycoprotein pair PEN5-alpha and PEN5-beta, monoclonal antibodies and immunoreactive fragments and derivatives thereof that bind to unique epitopes present on this molecule, and hybridomas that produce the antibodies. Methods of using the antibodies, fragments, and derivatives are also provided. The PEN5-alpha and PEN5-beta glycoproteins have apparent molecular weights of 120-150 and 210-245 kilodaltons, respectively, as measured by SDS-PAGE on 6 % polyacrylamide gels. The unique epitopes of the glycoprotein pair are preferentially expressed on the subpopulation of peripheral blood NK cells having the phenotype CD16?+ CD56dim¿ relative to their expression on peripheral blood NK cells having the phenotype CD16?+ CD56bright¿, and are not present on CD3+T lymphocytes or CD20+B lymphocytes. Figure 1 shows two-color flow cytometry histograms, which collectively reveal that the PEN5 epitope is expressed selectively on CD56?+ CD16dim¿ peripheral blood lymphocytes. |
| priorityDate |
1993-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |