http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0710652-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a17209ccc336ebb9b67deef73d6609da |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-19 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-19 |
| filingDate | 1995-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1998-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20369ea158f8833ba603d7b3c95bf226 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82045397926eda146da4e40d14a1c35a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ab749e32b52d3b18124c020716951a7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47b140fada525d374723f45f2c2232bd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f0e3712cc9d281928d0441a10836007 |
| publicationDate | 1998-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0710652-B1 |
| titleOfInvention | Process for preparing optically active piperazine derivatives and intermediates for preparation |
| abstract | Process for preparing optically active 2-piperazinecarboxylic acid derivatives, particularly S-enantiomer thereof, in high yield and high optical purity on industrial scale. As the optical resolving agents, easily accessible sulfonamides derived from selected optically active amino acids, such as N-tosyl-L-phenylalanine, N-tosyl-D-phenylglycine, N-tosyl-L-alanine or N-tosyl-L-valine, give excellent results. These resolving agents are stable and easily recovered from the reaction mixture and reused. Resolved 2-piperazinecarboxylic acid derivatives are preferably isolated as 4-t-butoxycarbonyl (Boc) derivatives. Diastereomeric salts (an example being shown below) formed as the intermediates of resolution are novel. <CHEM> ÄIn the formula "Ar" stands for a phenyl or naphthyl group which may be substituted with one to three C1-C6 alkyl groups, halogen atoms, nitro or alkoxy groups; and n=0 or 1.Ü |
| priorityDate | 1994-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 178.