| abstract |
A method is provided for making a substituted benzene compound which comprises: reacting a 2-substituted benzenesulfonate, or the 2-substituted benzenesulfonate further substituted in the 3,4 or 5-position, with a lithium compound to form an intermediate; and reacting the intermediate with an electrophile to form a 2,6-disubstituted benzenesulfonate or a 2,6-disubstituted benzenesulfonate further substituted in the 3,4 or 5-position. |