http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0705272-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69c91bbf0395db010b4806f50d808c4e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J73-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J73-005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J73-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J- |
| filingDate | 1993-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2002-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9285893b481b80094c16420fe858a21e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3daa1cae6c12277a17149c9fab9cdc1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edc236997e74ca07de23174ccffb10bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f75d131b9758816c2ad7b6871844480f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b15db5230621d5d38da2ec272a3baefe |
| publicationDate | 2002-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0705272-B1 |
| titleOfInvention | Novel process for preparing 17 beta-substituted 4-azaandrostane derivatives |
| abstract | The invention relates to a novel process for preparing 17 beta -substituted 4-azaandrostane derivatives of general formula (I) wherein R represents hydrogen or a C1-3alkyl group; R<1> represents a carboxamido group mono- or disubstituted by C1-8alkyl group(s); or a free carboxyl group; or a carboxyl group esterified with a C1-5 alcohol; and the - &cir& _- &cir& _- &cir& _- &cir& _ bond line represents a single or double bond; as well as their salts. The process comprises reacting a 17-halogeno-4-azaandrostene derivative of general formula (II) wherein R and the - &cir& _- &cir& _- &cir& _- &cir& _ bond line are as defined above, and X is chlorine, bromine or iodine, with a primary or secondary alkylamine or a C1-5 alcohol, in dimethylformamide or dimethylsulfoxide medium in the presence of a palladium(II) salt and phosphines or a palladium(II) complex and a tertiary amine base in carbon monoxide atmosphere at a temperature between 35 DEG C and 80 DEG C, then, if desired, transforming an obtained compound of general formula (I) to another compound of general formula (I) by hydrogenation, hydrolysis or salt forming reaction. |
| priorityDate | 1993-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 175.