| abstract |
PCT No. PCT/JP94/00786 Sec. 371 Date Nov. 9, 1995 Sec. 102(e) Date Nov. 9, 1995 PCT Filed May 12, 1994 PCT Pub. No. WO94/26709 PCT Pub. Date Nov. 24, 1994Guanidine derivatives of the formula: <IMAGE> (I) wherein Y is C-R1 (in which R1 is hydrogen, lower alkyl, hydroxy, protected hydroxy, etc.,) R2 is pyrrolyl, tetrazolyl, pyrazolyl, etc., R3 is hydrogen, lower alkoxy, hydroxy, protected hydroxy, etc., Z is C-R4 (in which R4 is hydrogen, carboxy, protected carboxy, nitro, halogen, hydroxy(lower)alkyl, etc.,), and W is R12 (in which R12 is hydrogen, lower alkoxy, nitro, hydroxy or protected hydroxy) and pharmaceutically acceptable salts thereof which are useful as a medicament which are useful in inhibiting Na+/H+ exchange in cells and in the prevention of cardiovascular diseases, cerebrovascular diseases, renal diseases, arteriosclerosis and shock. |