abstract |
2-Oxo-3-phenyl-oxazolidine-5-carboxylic acid derivs. of formula (I) and their isomers, salts and solvates are new:R1 = NO2, NR6R7, etc., or CH2NHCONH-Ph-E or D; X = OH, OA, AA, AA-AA' or a gp. of formula (X1)-(X3): E = e.g. CN; Y = CH2, CHOR5 or CO; R2 = H, A, Ar, etc.; R3 = (CH2)mCOOR5; R4 = (CH2)pCOOR5 or (CH2)qO(CH2)rCOOR5; AA,AA' = opt. protected amino acid residues selected from e.g. Ala, beta -Ala, Arg, etc.;R5-R7 = H or A; m = 1-3; n = 1-4; p = 0-2; q = 0 or 1; r = 1 or 2; A = 1-6C alkylene; Ar = phenyl or benzyl; Ph- = phenylene. |