| abstract |
A benzimidazolesulfonamide derivative of the formula (I):n n wherein R¹ is an alkyl group of 1 to 6 carbon atoms or a haloalkyl group of 1 to 6 carbon atoms; R² is a hydrogen atom, an alkyl group of 1 to 6 carbon atoms, a haloalkyl group of 1 to 6 carbon atoms, -OR⁴, -O(CH₂) m C₆H₅, -(CH₂) n C₆H₅, -NH₂, -NHR⁵, -NHC(=O)R⁶, -N(R⁷)₂, -NHC(=O)(CH₂) p C₆H₅, or -NHC(=O)CH(C₆H₅)₂; R³ is an azole group, -COOH, -COOR⁸ ,or -SO₃H; A is -O-, -NH-, or -S(O) q -; R⁴, R⁵, R⁶, R⁷, and R⁸ are independently an alkyl group of 1 to 6 carbon atoms; m, n, and p are independently 0 or an integer of 1 to 6; and q is 0, 1, or 2, or a salt thereof; and a pharmaceutical composition comprising the above compound are disclosed. The compound exhibits a stable and strong antagonism to angiotensin II. |