| abstract |
2.1. In known processes in which optically active L-amino acids of the general formula (II) where R stands for a bulky, branched, at least one tertiary carbon atom-containing alkyl group with 5 - 10 carbon atoms, there are problems with sterically demanding radicals R in terms of reaction and yield.n n n 2.2. The fact that an α-ketocarboxylic acid of the general formula I where R stands for a space-filling, branched, at least one tertiary C atom-containing alkyl group with 5 - 10 C atoms, is reductively aminated by a co-factor-dependent enzymatic reaction using dehydrogenases, the production of sterically very demanding L- Amino acids in satisfactory yield and good enantiomeric purity. n n n 2.3. Optically active (S) -amino alcohols, 4-substituted (S) -2-oxazolidinones, intermediates for active pharmaceutical ingredients, building blocks in asymmetric synthesis. |