| abstract |
An anthranilic acid derivative having a cGMP-PDE inhibitory activity and represented by general formula (I), or a pharmacologically acceptable salt thereof wherein R<1>, R<2>, R<3> and R<4> represent each independently hydrogen, halogen, hydroxy, optionally halogenated lower alkyl, optionally halogenated lower alkoxy, nitro, hydroxyalkyl, cyano, etc.; R<5> and R<6> represent each independently hydrogen, halogen hydroxy, cyano, optionally halogenated lower alkyl, optionally halogenated lower alkoxy, etc.; W represents -N= or -CH=; R<7> and R<8> represent each independently hydrogen, optionally halogenated lower alkyl, etc.; A represents hydrogen, optionally halogenated lower alkyl, etc.; Z represents hydroxy, optionally halogenated lower alkoxy, cyano, halogen, etc.; Y represents oxygen or sulfur; and n represents an integer of 0, 1 to 6. <CHEM> |