| abstract |
A novel isoxazolidinedione derivative represented by general formula (I) or a medicinally acceptable salt thereof, wherein R represents an optionally substituted aromatic hydrocarbon group, optionally substituted cycloaliphatic hydrocarbon group, optionally substituted heterocyclic group, optionally substituted fused heterocyclic group, or the group (II), R₄ represents hydrogen or lower alkyl; R₅ represents lower alkyl; and P and Q represent each hydrogen, or P and Q are combined with each other to represent a bond. The derivative and salt thereof have excellent hypoglycemic and blood lipid lowering activities and hence are promising as remedies for diabetes and complications thereof and for the related diseases such as hyperlipemia. |