| abstract |
According to this invention, antibodies which are useful and novel in that they have binding specificity to beta -amyloids or derivatives thereof, namely recognize the N-terminal, the C-terminal or central portions of the beta -amyloids, respectively, were obtained. By combining these antibodies, determination methods by which the beta -amyloids could be determined sensitively and specifically are provided. These determination methods are useful for diagnosis of diseases to which the beta -amyloids or their derivatives are related (for example, Alzheimer's disease), and the antibodies of this invention are useful for the development of preventive-therapeutic compositions for Alzheimer's disease. |