http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0680964-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aff6633139e8f79659a0587cc38a6c07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 1994-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2002-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd5f8f9d8a409fb547f0c8cf0af7747f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1f37bcca06d45fe285019cdf6a0ce7b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe7c50fb1ac010ef5f9447564c474a00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0bd05768cb1297933c027fdf725da465 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff0a8b750753626a1c6ad8e271a76ee2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_657131f964a4b259515ebfaface311f3 |
| publicationDate | 2002-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0680964-B1 |
| titleOfInvention | PYRROLO [3,2-e]INDOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND THEIR USE |
| abstract | The new pirrolo [3,2-e]indol derivatives have the formulae (I), (Ia) and (II) wherein R is substituted or unsubstituted aryl or heteroaryl, R' is substituted or unsubstituted alcanoyl, alkenoyl, alkinoyl, arenocarbonyl or heterareocarbonyl and X is chloro, bromo, iodo or alkylsulfonyl or arylsulfonyl. The process comprises: (a) deacylating (VII) in order to obtain (VIII); (b) subjecting (VIII) to a cyclopropyl ring opening raction in order to give (IX); (c) reacting (IX) with acid R-COOH in order to yield (I); (d) optionally, reacting (I) with a base in the presence of a condensing agent in order to obtain (II); (e) optionally, reacting (I) with a carboxylic acid in the presence of a condensing agent or with an acid chloride in the presence of a base to give (Ia). The compounds (I), (Ia) and (II) find application as agents having antitimoral activity for the treatment of cancer. <CHEM> |
| priorityDate | 1993-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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