abstract |
A pharmaceutical composition comprises a single dose capsule for oral administration containing an organic nitrate, preferably isosorbide 5-mononitrate and acetylsalicylic acid. A coating on one or both of the organic nitrate or acetylsalicylic acid provides a barrier between them. Portion of the organic nitrate in the capsule is in a form for immediate release and portion is in a form for slow release. |