http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0675134-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_880cc8535f892eca8121f608c316808c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0094 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J15-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 |
| filingDate | 1995-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1999-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa6893f4c4fb50ccca8b8ad332e393d9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a76140226dfb6a1a8a9cadace555aa19 |
| publicationDate | 1999-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0675134-B1 |
| titleOfInvention | New 20-amino substituted steroid compounds, a method for their production and intermediates therefor and pharmaceutical compositions containing them |
| abstract | 20-(aminoalkylamino)-19-norpregna-1,3,5(10)-trien-3-ol cpds. of formula (I) and their acid addn. salts are new: R1, R2 = 1-12C alkyl or 7-15C aralkyl; or NR1R2 = 5- or 6-membered satd. heterocycle opt. contg. a further N, O or S heteroatom; R3 = 1-8C alkyl; n = 2-15; R4 - 1-12C alkyl; R5 = H, up to 12C acyl or 1-12C alkyl; the 17 and 20 asymmetric centres independently have R or S absolute configuration. In an example, 3.03 g (20S) (8 alpha , 9 beta , 13 alpha , 14 beta , 17 beta )-2- dimethylamino-N-(3-hydroxy-19-norpregna-1,3,5,(10)-trien-20-yl)- acetamide was added under inert gas at 20 degrees C. to a mixt. of 1.845g LiAlH4, 5.25g AlCl3 and 131 ml THF. The mixt. was refluxed for 24 hrs., cooled to 0-5 degrees C. and treated with 20 ml EtOAc then 100 ml satd. aq. NaCl. The suspension was filtered then successively taken up in water 16N HCl (80 ml/50 ml), filtered, taken up in 60 ml 60% EtOH/8 ml NEt3 and filtered. The soln. was treated with water for pptn. extd. with CH2Cl2, washed, dried, treated with active carbon and evapd. The dry residue (1.9g) was dissolved in 60 ml EtOHc/4 drops NEt3 for 15 mins. at reflux. The soln. was concd. to 30 ml and cooled at 0-5 degrees C. for 1 hr. The residue was recovered by centrifuge and dried to give 1.03 g (Ia), m.pt. 177 degrees C.. Ä alpha Üp = -80.6 degrees (c = 0.5%, EtOH). |
| priorityDate | 1994-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 76.