http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0672188-A4

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filingDate 1993-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15e755248535d2a4365207cf555dfe1e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f24d041eec12593a62842baf6aac8bf5
publicationDate 1999-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0672188-A4
titleOfInvention STRUCTURE-BASED NUCLEIC ACID SELECTION PROCESS.
abstract A method of selecting nucleic acids on the basis of physical structure is disclosed. A modification of the Systematic Evolution of Ligands by Exponential enrichment (SELEX) is used in conjunction with methods of differentiating between nucleic acid molecules on the basis of physical structure, such as chromatography, gel electrophoresis, solubility, and solvent partitioning. The disclosed method may be used in selecting single stranded DNA or RNA, or double stranded DNA or RNA. An example of the method selected nucleic acids of bent DNA. This method represents a new and powerful approach to select nucleic acid molecules with the physical structure required for specific biological activity, for example, in the regulation of gene expression.
priorityDate 1992-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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