| abstract |
Compounds of formula (I), wherein ring A is a ring of formula (AI) or (AII) (in which the spiro atom is indicated by *), R1 represents H or alkyl C¿1-6; R?2 represents -(CH¿2)n-OR?3, -(CH¿2?)m-C(O)R?4¿, fluoroalkyl C¿1-6?, cyanoalkyl C1-6 or alkyl C1-6 substituted with a 4-7 membered optionally unsaturated heterocyclic ring; R?3¿ represents H, alkyl C¿1-6? (optionally substituted with alkoxy C1-6), cycloalkyl C4-7, a 4-7 membered optionally unsaturated heterocyclic ring, phenyl (optionally substituted with halogen, hydroxy or alkyl C1-6), or benzyl (optionally substituted with halogen, hydroxy or alkyl C1-6); R?4¿ represents OR?5, NR6R7, N(OR6)R7¿ or alkyl C¿1-6; R?5 represents H, alkenyl C¿2-6?, alkynyl C2-6 or alkyl C1-6) optionally substituted with phenyl); R?6 and R7¿ independently represent H or alkyl C¿1-6; R?8 represents H or alkyl C¿1-6?; n is 2-5; m is 1-5; p is 1 or 2; and pharmaceutically acceptable salts thereof; are useful in the treatment of neurodegenerative disorders. |