| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3a2b4cfc48c3eb7151590020c6bbc02c |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-357
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-256
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D305-14 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D305-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-256
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-357
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 |
| filingDate |
1993-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2002-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d378042869002a3429d4aece11df4b5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_596a19d23f943463922cd989069bc751
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a59c314d7fef83efd7eae7de68f89aed
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_381e2e23bcf13db395da21c17d8adf43 |
| publicationDate |
2002-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0668862-B1 |
| titleOfInvention |
Oxidation of glycoside substituted taxanes to taxol or taxol precursors and taxane compounds formed as intermediates |
| abstract |
A process for the conversion of glycoside substituted taxanes to taxol and related compounds that can serve as precursors to taxol. The process includes the oxidation of glycoside substituted taxanes to convert the glycoside to the hydroxyl group. The oxidation can occur in the presence of an acid or followed by treatment with acid. Application of the process to 7-xylosyl taxol ('XT') yields taxol; application to other glycoside substituted taxanes forms compounds that can serve as precursors for taxol. The process includes the formation of certain new taxol related intermediate compounds having a hemialdal at the C-7 site on the taxane ring, which hemialdal can then be converted to taxol or taxol precursors. Since glycoside substituted taxanes are isolated with taxol from naturally occurring biomass, their conversion to taxol using the process of the present invention significantly improves the total yield of taxol from natural sources. |
| priorityDate |
1992-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |