| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_81b41a5ff6a6e50374ee9f5ba8ace0c8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_184e99c06225bda4190dff359deb4b1e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9c7abdc80bc83287c4791175ab8b3d93
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_48423c012bdb0790971ced05d59e3cfc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ae0b34c05e6ac03028df484b1c40c45d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7f9201b40d1eeed7b7c448bdc4ef5283 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-94
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-9486
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-485 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-94
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-485
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 |
| filingDate |
1993-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_330b49190a89e0699969380fa22c8643
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa0cb2341a164c5b5e6f6656a200f070
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c870fed310e682bb3b169c42866eb650
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b58d5a2e3bf0910cf637570697e76329
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31e64248a3a9bc7e66c2bfb8487011fa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19752bd2f88a1dd819358f89d67656d3 |
| publicationDate |
1995-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0668764-A1 |
| titleOfInvention |
Methods for identifying and using low/non-addictive opioid analgesics |
| abstract |
The present invention relates to a method of using a bioassay consisting of an electrophysiological method and a cell culture system of dorsal-root ganglion (DRG) neurons to screen and identify opioids with a high potential for use as 'low- or non-addictive' analgesics. Another aspect of the invention relates to a specific group of opioid alkaloids and analogues thereof identified by the bioassay of the invention for the unique ability to activate only inhibitory, but not excitatory, opioid receptor function, for use as low- or non-addictive analgesics. Another aspect of the invention relates to the specific use of etorphine or dihydroetorphine of the opioid alkaloid family as low- or non-addictive analgesics and for the treatment of opioid addiction. The present invention also relates to the preparation of dihydroetorphine hydrochloride (7α-[1-(R)-hydroxy-1-methylbutyl]-6,14-endo-ethano-tetrahydrooripavine hydrochloride) and a pharmaceutical composition comprising the compound as an active ingredient in the form of a pharmaceutically acceptable salt. |
| priorityDate |
1992-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |