| abstract |
This invention provides a novel purified TGF-β binding glycoprotein, endoglin, and isolated nucleic acid molecules that encode amino acid sequences corresponding to the TGF-β-binding glycoprotein. Also provided is soluble endoglin-derived polypeptide, and fragments thereof. A pharmaceutical composition which comprises the purified endoglin-derived polypeptide or produced recombinantly methods and a pharmaceutically acceptable carrier is further provided as well as methods of treating patients by administering to the patient the pharmaceutical compositions of this invention. |