| abstract |
A method of manufacturing a composition for solid medicine having a controlled elution rate and containing as active ingredients a potassium channel activator and a pharmaceutically permissible water-insoluble macromolecular substance of cellulose, comprising the steps of dissolving a potassium channel activator in a solvent to obtain a medical solution, adding the medical solution to a water-insoluble macromolecular substance of cellulose which is inactive with respect to the solvent, and which has a quantity necessary and sufficient to obtain a predetermined elution rate, and mixing them together uniformly, and then drying the resultant mixture so as to remove the solvent therefrom; and a solid medical composition obtained by this manufacturing method. According to the method of the present invention, the elution rate of the active component of the potassium channel activator-containing medicine, a sustained release medicine, can be controlled easily and highly reproducible. |