http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0666869-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_916075766043ce900399a4c2eee9f054 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5154 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-805 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-805 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 |
| filingDate | 1993-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa2d5dca7fe777da44b01401250ef8b2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69d341034f14da898011f4327dfb1480 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c3e0d15393e489e3e4ad06b61080806 |
| publicationDate | 1995-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0666869-A1 |
| titleOfInvention | Peptides tolerizing t-cells and compositions thereof |
| abstract | The present invention provides a tolerizing peptide and a therapeutic composition containing at least one such tolerizing peptide which when administered to an individual in a therapeutically effective amount is capable of tolerizing at least a portion and preferably all of the T cells of said individual which are specific for an antigen (e.g. an allergen, an autoantigen or a transplantation antigen), said tolerizing peptide having the ability to combine with MHC proteins on antigen presenting cells (APC) and cause binding of T cell receptors on at least a portion of the T cells of an individual to said peptide-MHC complex. Said tolerizing peptide preferably has the ability to cause no detectable or minimal proliferation of at least a portion of the T cells of an individual which are specific for said antigen when said peptide is administered in vivo in immunogenic form. The invention also provides a method for treating sensitivity to a particular antigen in an individual and a method for tolerizing at least a portion of a population of T cells in an individual which are specific for an antigen. |
| priorityDate | 1992-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.