| abstract |
A phosphonic diester derivative represented by general formula (1), wherein R¹, R² and R³ are the same or different from one another and each represents hydrogen, lower alkyl, halogeno, cyano, hydroxy or lower alkoxy which may be substituted by halogen, phenyl or hydroxypiperidino; R⁴ represents hydrogen, lower alkoxy, halogeno or lower alkyl which may be substituted by halogeno or cyano; and R⁵ and R⁶ are the same or different from each other and each represents hydrogen or lower alkyl. This derivative is excellent in hypolipemic, hypotensive and hypoglycemic effects and is useful for treating and preventing hyperlipemia, hypertension and diabetes. |