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filingDate 1989-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1995-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0664298-A1
titleOfInvention Sex-associated membrane proteins and methods for increasing the probability that offspring will be of a desired sex
abstract A method of sorting living cells based on DNA content. Mammalian sperm subpopulations enriched in X- or Y-sperm. X- and Y-enriched sperm-plasma-membrane vesicles. Substantially pure sex-associated membrane (SAM) proteins. Antibodies binding to X- or Y-SAM proteins, essentially free of antibodies binding to Y- or X-SAM proteins respectively, or to the H-Y antigen. Semen samples enriched for X- or Y-sperm. Methods for increasing the probability that offspring will be male or female comprising the step of allowing a sperm from an enriched semen sample to fertilize an ovum. Methods for increasing the probability that offspring will be male or female comprising the step of immunizing a female with X- or Y-SAM proteins. Methods of decreasing fertility comprising the step of immunizing a female with both X- or Y-sperm. Methods of increasing the probability that mammalian offspring will carry a gene for a particular sex-chromosome linked trait.
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