| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c2acaafc4374e6a678f2609d547c762e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-775
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1275 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-775
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| filingDate |
1994-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2002-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2aa0b9d198b395a9625677c8e1cb0117
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e274c050aa5a8abe41663ac4dde1fb8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_905744bb8026577d58d2191cd8e2d078 |
| publicationDate |
2002-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0663407-B1 |
| titleOfInvention |
Process for preparation of reconstituted lipoproteins |
| abstract |
Industrial prodn. of a compsn. (A), contg. reconstituted lipoprotein particles (LPP), comprises first mixing an aq. apolipoprotein (APL) soln. of protein content 1-40 g/l with an aq. lipid(L)-detergent (D) soln., at mole ratio L:D 1:0.5-4 and wt. ratio APL:L 1:1.5-5.The resulting mixt. was incubated at a temp. within 10 degrees C of the phase transition temp. of L in water, then the detergent removed (by exclusion according to mol. size or by using an adsorbent) so that LPP of dia. 5-50 nm and mol.wt. 0.05-1 MD are formed. Without further purificn. steps, over 95% of added protein and over 90% of total L is bound in LPP.Opt. the resulting liq. prod. is lyophilised in presence of a carbohydrate stabiliser.(A) contains 18-22 g/l protein and, at 18-22 degrees C, has turbidity below 40 NTV. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7592008-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7575763-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7691414-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7662410-B2 |
| priorityDate |
1993-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |