| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-4866
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21069
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6464
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-745 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-36 |
| filingDate |
1995-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2001-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6309c690b5fd2c4059d80c3432048a7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94f371d5ce5bfb54bc8c92aa94524db3 |
| publicationDate |
2001-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0662513-B1 |
| titleOfInvention |
Methods for preventing degradation of protein C |
| abstract |
The present invention relates to methods to prevent or minimize autodegradation of activated protein C. The invention is best exemplified by performing the processing, purification and/or storage of the activated protein C at low pH, for example at about pH 6.3 to about pH 6.5. Autodegradation of aPC may also be minimized by incubating the aPC in 3 M urea (complete recovery of aPC activity is obtained after the removal of the denaturant) or by incubating the aPC in the presence of extreme salt concentrations. The present invention also comprises aPC formulations which maintain the aPC at low pH, in denaturant, or at extreme salt concentrations. |
| priorityDate |
1994-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |