| abstract |
PCT No. PCT/EP93/02042 Sec. 371 Date Mar. 16, 1995 Sec. 102(e) Date Mar. 16, 1995 PCT Filed Jul. 30, 1993 PCT Pub. No. WO94/06929 PCT Pub. Date Mar. 31, 1994The invention relates to a novel epitope of 180,000 daltons for the NCAM antigen and a monoclonal antibody, SEN7, directed against this antigen, and their use in diagnosis and therapy of small-cell carcinoma of the lung. The antibody SEN7 reacts significantly more selectively than previously known antibodies with cells of small-cell carcinoma of the lung, and binds with high avidity. In particular, no reaction occurs with leucocytes or healthy kidney or lung epithelial cells. The novel antigen is dominantly expressed by cells of small-cell carcinoma of the lung with a high copy number. |