http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0662127-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f90c6951f7897cacf4008781b253a453 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f46488b9abd626f2f11b8dd0e69126da |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0271 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
| filingDate | 1993-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61053f73c66ffc719c31836bcf700178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_837f52665188d102fbe2171a890f992d |
| publicationDate | 1995-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0662127-A1 |
| titleOfInvention | Testing individual immune response to an antibody with scid mouse |
| abstract | This patent application concerns a method for testing a patient's (P) individual immune response to an antibody 'X' or binding fragment thereof which is specific for an epitope of a mediator of the patient's immune response against an antigen 'Z' which method comprises the steps of: (i) isolating a sample of peripheral blood leucocytes (PBL) from the patient; (ii) engrafting a mouse having severe combined immunodeficiency (SCID) with said sample in order to create a p-PBL-SCID test mouse having PBLs of the patient; (iii) treating said test mouse with a tolerogen designed for administration to the patient so as to reduce the patient's immune response to antibody 'X'; (iv) after step (iii) immunising said test mouse with antibody 'X'; (v) after (iii) and (iv) detecting any human antibody response in said test mouse; wherein the tolerogen comprises a water-soluble covalent conjugate of an antibody 'Y' with one or more non-immunogenic water soluble polymers and wherein said antibody 'Y' although different from antibody 'X' has structure in common with it. |
| priorityDate | 1992-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 111.