| abstract |
A tricyclic indole-2-carboxylic acid derivative represented by the formula 1 :n n wherein X represents alkyl, halogen or cyano; n R¹ represents hydrogen, or a protecting group of carboxyl group; n W represents hydrogen, -CO₂R 3i , -CONR 3i R 4i , -A-CO₂R 3i or -A-CONR 3i R 4i , wherein -A- represents alkylene and R 3i and R 4i independently represent hydrogen, alkyl, aryl or substituted aryl, n or a pharmaceutically acceptable salt thereof, these compounds are selective antagonists of glycine binding site of the NMDA receptor. |