| abstract |
A method of lowering serum cholesterol levels comprising administering to a human in need of treatment an effective amount of a compound having the formulan n wherein R is hydrogen; hydroxy; C₁-C₆ alkoxy; a group of the formula -O-C(O)-R a , wherein R a is hydrogen, C₁-C₆ alkyl optionally substituted with amino, halo, carbonyl, C₁-C₆ alkoxycarbonyl, C₁-C₇ alkanoyloxy, carbamoyl and/or aryl; or R a is C₁-C₆ alkenyl optionally substituted with aryl; or R a is a C₃-C₇ cycloalkyl; or R a is aryl optionally substituted with hydroxy, C₁-C₆ alkyl, C₁-C₆ alkoxy, and/or halo; or R a is -O-aryl, said aryl optionally substituted with hydroxy C₁-C₆ alkyl, C₁-C₆ alkoxy, and/or halo, n or R is a group of the formula -O-SO₂-R b wherein R b may be C₁-C₆ alkyl or aryl optionally substituted with C₁-C₆ alkyl; n or R is carbamoyloxy wherein the nitrogen may be substituted once or twice with C₁-C₆ alkyl; n or R is a group of the formula -O-C(O)R c -O-(C₁-C₆ alkyl) wherein R c is a bond or C₁-C₆ alkanediyl; n R¹ is halo, C₁-C₆ alkyl, C₁-C₇ alkyl substituted with C₁-C₆ alkyl, substituted or unsubstituted C₃-C₇ cycloalkyl, or substituted or unsubstituted C₃-C₇ cycloalkenyl; n R² is O or CH₂; n R³ is CH₂ or (CH₂)₂; n R⁴ isn n CH₂, or a bond; and n R⁵ is amino, nitrilo optionally substituted once or twice with C₁-C₆ alkyl; or an N-heterocyclic ring which optionally has another hetero atom selected from N, O, or S in said ring; or a pharmaceutically acceptable salt or solvate thereof. |