http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0655455-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2baf849d216e689ecc40ccc931a7a7bc |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-665 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-675 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-657181 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-675 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-665 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6571 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6558 |
| filingDate | 1989-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_90addc1d2804d5989e5f1d3ff291be90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9257fba4766a3795d0129dfcae01eaf3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_135a67edb3b1f8eb7cdf4b421c57687f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cabed9c0cdfdd5e2ec89dffcd8defd67 |
| publicationDate | 1995-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0655455-A1 |
| titleOfInvention | Novel phosporus containing pyridine derivatives |
| abstract | A pyridine compound of a formula I:n n wherein Ar¹ is phenyl, pyridyl, furyl or 2,1,3-benzoxadiazol-4-yl, which maybe substituted by one or two substituents selected from the group consisting of NO₂, CF₃, Br, Cl, F, R⁶ (wherein R⁶ is C₁-C₄ alkyl), OH, OR⁶, OCHF₂, COOR⁶, NH₂, NHR⁶, NR⁶R⁷ (wherein R⁷ has the same meaning as R⁶), CONH₂, CONHR⁶, CONR⁶R⁷, COSR⁶, SR⁶, S(O)R⁶, S(O)₂R⁶, SO₃H, SO₃R⁶, SO₂NH₂, SO₂NHR⁶, SO₂NR⁶R⁷, CN and phenyloxy; n the nitrogen-containing hetero ring portion represents a 1,4-dihydropyridine ring or a pyridine ring; n Z is a group of the formula II:n n wherein each of R⁴ and R⁵ which may be the same or different is OH, C₁-C₁₂ linear or branched primary or secondary alkyloxy, C₃-C₆ linear or branched unsaturated alkyloxy, C₃-C₆ cycloalkyloxy, C₁-C₆ alkyloxy substituted by C₃-C₆ cycloalkyl, OAr² (wherein Ar² is phenyl which may be substituted by halogen, C₁-C₃ alkyl or C₁- C₃ alkyloxy), OANR⁶R⁷ (wherein A is C₂-C₆ alkylene, which may be substituted by C₁-C₃ alkyl or Ar²), OAN(CH₂Ar²)R⁶, OAOR⁶, OACN, NH₂, NHR⁶, NR⁶R⁷, 1-piperidinyl or 1-pyrrolidinyl, or R⁴ and R⁵ together form OYO (wherein Y is C₂-C₄ linear saturated or unsaturated alkylene which may substituted by R⁶, CO₂R⁶, OR⁶, or A), NHYO, R⁶NYO, NHYNH, R⁶NYNH or R⁶NYNR⁷; n R¹ is present only when the nitrogen-containing hetero ring is a 1,4-dihydropyridine ring, and it is AN(CH₂CH₂)₂O; n R² is R⁶, Ar², Ar²CH=CH, Ar²CH(OH)CH₂, CHO, CN, CH₂OH, CH₂OR⁶, CH₂CH₂N(CH₂CH₂)₂NR⁶, NH₂, NHR⁶ or NR⁶R⁷; n R³ is hydrogen, C₁-C₁₂ linear or branched alkyl, C₃-C₆ linear or branched unsaturated alkyl, C₃-C₆ cycloalkyl, C₁-C₆ alkyl substituted by C₃-C₆ cycloalkyl, AOR⁶, AO(CH₂) m Ar² (wherein m is an integer of from 0 to 3) , (CH₂) m Ar², ANH₂, ANHR⁶, ANR⁶R⁷, ANR⁶(CH₂) m Ar², AN {(CH₂) m Ar²} {(CH₂) n Ar³} (wherein n has the same meaning as m, and Ar³ has the same meaning as Ar²), 1-benzyl-4-piperidinyl, 1-benzyl-2-piperidinyl, 2-pyridinylnethyl, 3-pyridinylmethyl, AQ (wherein Q is pyrrolidine or piperidine which may be substituted by (CH₂) m Ar²), 4-R⁶-1-piperazinyl, 4-Ar²-1-piperazinyl, 4-(Ar²)₂CH-1-piperazinyl or 4-(Ar²)₂CH-1-(1,4-diazacycloheptyl); n or a pharmaceutically acceptable salt of the compound. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-19852345-A1 |
| priorityDate | 1988-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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