http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0653438-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5929f2d6f4dba84be8dd3a8ba633db12 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70 |
| filingDate | 1994-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7041f2db0cc90590a345cb1e4e8bd9ca http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce3701c9e4b7a7416065d4150ac979dc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10f1fb0675cc0accf8d8fb54ec50736c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab90314742bfff35b7f012bd9762f5f0 |
| publicationDate | 1995-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0653438-A2 |
| titleOfInvention | Oligonucleotide compounds, their production and use |
| abstract | An oligonucleotide compound or a salt thereof, which has a nucleotide sequence represented by formula (I):n nwherein W represents hydrogen or a protective group; B 1 , B 2 and B 3 each represent nucleic acid residues, wherein each B 2 may be the same or different when n is 2 or more; X 1 , X 2 and X 3 each represent OH, SH, C 1-5 alkyl, C 1 - 5 alkoxy, C 1 - 5 monoalkylamino or an aromatic ring group which may be substituted or unsubstituted, wherein each X 3 may be the same or different when n is 2 or more; R 1 , R 2 and R 3 each represent hydrogen, OH, halogen, C 1 - 5 alkoxy or C 1 - 5 alkoxyalkyloxy, wherein each R 2 may be the same or different when n is 2 or more; and n represents an integer from 1 to 98 is disclosed. n The oligonucleotides (I) of the present invention or the salts thereof can (1) inhibit expression of genes associated with the development of malignant tumors in malignant tumor cells, (2) inhibit expression of viral genes derived from viruses, (3) inhibit expression of genes producing proteins which contribute to the development of inflammations, (4) control expression of drug-resistant genes which cause complications in chemotherapy of malignant tumors, and (5) inhibit production of cell growth factors related to reangiostenosis after PCTA (percutaneous transluminal coronary angioplasty) by complementation to DNAs or mRNAs of genes inducing various diseases. They can be therefore used as antitumor agents, antiviral agents, antiinflammatory agents and drugs for controlling expression of specific genes such as resistance genes. These oligonucleotides can also be used as probes. Further, these oligonucleotides can be used in novel drug screening assays. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9634008-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9832467-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9832467-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5747338-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2733500-A1 |
| priorityDate | 1993-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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