| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_61f88efcda59d7062a4252ecf6886f58 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1271
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6843
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6913 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 |
| filingDate |
1993-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c623721631b9891a9f1b04c37fb142b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99dadb501b3b7599eea87b2b360fff22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6cad2c0853a86c2953e022cf0fe31f13 |
| publicationDate |
1995-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0652775-A1 |
| titleOfInvention |
Targeting of liposomes to the blood-brain barrier |
| abstract |
The present invention is directed to the targeting of drugs, peptides, and proteins to the brain. Liposomes containing the compound to be delivered are coupled to antibody binding fragments which bind to receptors on the vascular endothelium of the blood-brain barrier. The targeted receptors include transferrin receptor, insulin receptor, IGF-I and IGF-II receptors, among others. Also provided are pharmaceutical compositions and methods for administering the drugs to a subject in need by means of the receptor-targeted immunoliposomes. |
| priorityDate |
1992-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |