abstract |
A method of inhibiting cartilage degradation comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formulan n wherein R¹ and R³ are independently hydrogen, -CH₃,n n orn n wherein Ar is optionally substituted phenyl; n R² is selected from the group consisting of pyrrolidino and piperidino, a pharmaceutically acceptable salt or solvate thereof. |