| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_03d111d6dcb3d7a07e4e766163463ff9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-75 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-1019
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-003
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4716
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1072
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-475
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-62 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-107
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-475
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
| filingDate |
1993-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2002-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88c56a3ecbb95fa26a10dd3c6a905437
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61c0661ea6379b54e925b552a343c8eb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08d6b137ef3af804e272b183a9cb4f02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e90b238b970433bf5a0f19f66c1bc77 |
| publicationDate |
2002-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0651761-B1 |
| titleOfInvention |
Method for modification of recombinant polypeptides |
| abstract |
The present invention provides for a method of preparing a modified recombinantly produced polypeptide including a reactive side chain group and a modified N-terminal alpha -amine group or C-terminal alpha -carboxyl group, the method comprising the steps of recombinantly forming a polypeptide having a biologically added protecting group on an N-terminal alpha -amine group or C-terminal alpha -carboxyl group, cleaving the biologically added protecting group with a cleavage reagent to form the unprotected terminal amino acid alpha -carbon reactive group and modifying the unprotected terminal amino acid alpha -carbon reactive group with a chemical modifying agent to form a terminally modified polypeptide. The invention further provides for a biologically added protecting group for a recombinantly produced polypeptide comprising a peptide or amino acid, said biologically protecting group being stable under conditions for chemical protecting reactions and including an enzymatic cleavage recognition site and a chemical cleavage recognition site, wherein the recognition sites are not present in the recombinantly produced polypeptide. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11340234-B2 |
| priorityDate |
1992-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |