| abstract |
Disclosed is a method of regulating the metabolic pathway of inositol in a cell. This method includes the introduction into said cell of a molecule which is then allowed to couple a membrane-bound receptor, activatable by an external signal, to an intracellular phosphodiesterase of the type responsible for generating second messenger substance, IP3. This molecule is selected from the group consisting of a purified A-protein, and active fragments, active analogs, and active fusion products thereof. Also disclosed are methods of detecting an A-protein and methods of inhibiting the growth and proliferation of cancer cells using anti-A-protein antibodies. |