| abstract |
Cyclopropane derivatives of the following general formula (I) or their pharmaceutically acceptable salts, are provided, as well as anti-viral agents containing the same as the active ingredient:n n wherein R¹ and R², which may be the same or different, each represents a hydrogen atom or an acyl group; R³ represents a halogen atom, a 2-haloalkyl group, a 2-halo-1-alkenyl group, or a 1-alkynyl group. The derivatives and their salts have anti-viral activity, for example against varicella zoster and herpes simplex, and may be used as alternatives to acyclovir. And intermediates of formulae (3) and (9)n n wherein R₄ is a protective group for a hydroxyl group and R₃ is defined as above. |