http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0646601-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_47e5ab274bf84662496d30977647afa9 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-63 |
| filingDate | 1994-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b00a65feddf65850d954d46d3eeacc1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d548af9748c9b8a3f7050fc1f7dbea0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_887f5989ebd8a6a5c236182538f824b1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_569a707c68b120041baa5a7518d9c0f0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e71f4eb2c992609beafcb640b0be9380 |
| publicationDate | 1995-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0646601-A1 |
| titleOfInvention | Motilin-like polypeptides with gastrointestinal motor stimulating activity |
| abstract | This invention pertains to polypeptides having gastrointestinal motor stimulating activity represented by the formula:n n wherein A is the L-stereoisomer of a lipophilic aliphatic or alicyclic amino acid; B is L-proline or L-alanine; D is the L-stereoisomer of a lipophilic aliphatic or alicyclic amino acid; E is the L-stereoisomer of an aromatic, lipophilic aliphatic, or alicyclic amino acid; F is the L-stereoisomer of an aromatic or heteroaromatic amino acid; G is glycine or D-alanine; H is L-glutamic acid or L-glutamine; I is L-glutamine, L-glutamic acid, or L-alanine; J is a direct bond or is selected from the group consisting of Z, Z-Leu, Z-Leu-Gln, Z-Leu-Gln-Glu, Z-Leu-Gln-Glu-Lys, Z-Leu-Gln-Glu-Lys-Glu, Z-Leu-Gln-Glu-Lys-Glu-Arg, Z-Leu-Gln-Glu-Lys-Glu-Arg-Asn, Z-Leu-Gln-Glu-Lys-GIu-Arg-Asn-Lys, and Z-Leu-Gln-Glu-Lys-Glu-Arg-Asn-Lys-Gly, wherein Z is selected from the group consisting of arginine, D-arginine, D-homoarginine, D-lysine, D-ornithine, D-2,4-diaminobutyric acid, D-glutamine, D-asparagine, and D-alanine; R₁ is lower-alkyl or allyl; R₂ is selected from the group consisting of hydrogen, lower-alkyl, propargyl, and allyl; R₃ is selected from the group consisting of hydrogen, lower-alkyl, and allyl; R₄ is selected from the group consisting of lower-alkyl, cycloalkyl, substituted and unsubstituted aryl, and heteroaryl, wherein the aryl substituents are selected from the group consisting of halogen, hydroxy, and lower-alkoxy; R₅ is selected from the group consisting of -CH₂CONH₂, aminoalkyl groups, and guanidinoalkyl groups; R₆ is -COOH or -CONH₂; and m is 0 or 1, with the proviso that (a) when m is 0, R₂ and R₃ are hydrogen, and J is a direct bond, the -NH-*CH(CH₂R₅)R₆ group has the D-configuration; (b) R₅ is -CH₂CONH₂ only when J is Z-Leu or Z-Leu-Gln-Glu-Lys-Glu-Arg-Asn-Lys-Gly; (c) when m=0, R₂ and R₃ are hydrogen, and J is Z, Z-Leu, Z-Leu-Gln, Z-Leu-Gln-Glu, Z-Leu-Gln-Glu-Lys, Z-Leu-Gln-Glu-Lys-Glu, Z-Leu-Gln-Glu-Lys-Glu-Arg, Z-Leu-Gln-Glu-Lys-Glu-Arg-Asn, Z-Leu-Gln-Glu-Lys-Glu-Arg-Asn-Lys, and Z-Leu-Gln-Glu-Lys-Glu-Arg-Asn-Lys-Gly, Z has the D configuration; and (d) the polypeptide is other than motilin. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0807639-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006138026-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8710184-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006138026-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0807639-A3 |
| priorityDate | 1993-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 376.