| abstract |
Corticoid-17,21-dicarboxylic acid esters and corticoid-17-carboxylic acid ester-21-carbonic acid esters of the formula I are described with A equal to CHOH and CHClm CH₂, C = O, 9 (11) double bond; Y is H, F, Cl; Z is H, F, methyl, R (1) is aryl, hetaryl; R (2) is alkyl, R (3) is H, methyl. They are obtained, inter alia, by a compound of the formula II, in which R (5) is OH, with an activated carboxylic acid of the formula III, R (6) -CO- (O) n - [(C₁-C₄) alkyl] m -R (1) III implements. They have a very strong anti-inflammatory effect locally and topically and show a very good ratio of local to systemic anti-inflammatory effects. Among other things, they serve as a means of treating inflammatory dermatoses. |